C4-Dicarboxylic acid cycle and Salmonella typhi.

Several papers have already been published for answering the question whether or not the tricarboxylic acid cycle or the C4-dicarboxylic acid cycle plays a role in microorganisms, and a summarizing description of the subject is seen in Ajl's article(1). Karlson and Barker(2), for example, stated that the tricarboxylic acid cycle does not operate in Azotobacter agilis, Barron, Ardao and Hearon (3) claimed, however, Corynebacterium creatinovorans to oxidize acetate via the dicarboxylic acid cycle. In the case of Escherichia coli, it has been insisted by Ajl(4) that not the tricarboxylic but the dicarboxylic acid cycle with the Knoop-Thunberg condensation is operating in an adapted way. In the present paper we are dealing with some adaptive growth patterns of Salmonella typhi using carbon compounds found in Krebs cycle pathway and a certain aspect of the problem with this organism will be discussed.